G protein-coupled receptor kinase 7

G protein-coupled receptor kinase 7
Identifiers
Symbol GRK7
Alt. symbols GPRK7
Entrez 131890
HUGO 17031
OMIM 606987
RefSeq NM_139209
UniProt Q8WTQ7
Other data
EC number 2.7.11.14
Locus Chr. 3 q24

G protein-coupled receptor kinase 7 also known as GRK7 is an enzyme which in humans is encoded by the GRK7 gene.[1][2][3]

Function

This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.[3]

References

  1. ^ Weiss ER, Ducceschi MH, Horner TJ, Li A, Craft CM, Osawa S (December 2001). "Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction". J. Neurosci. 21 (23): 9175–84. PMID 11717351. 
  2. ^ Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W (December 2001). "Characterization of human GRK7 as a potential cone opsin kinase". Mol. Vis. 7: 305–13. PMID 11754336. 
  3. ^ a b "Entrez Gene: GPRK7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131890. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.